Version 5.4
Homo sapiens Protein: PBX3
Summary
InnateDB Protein IDBP-85335.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PBX3
Protein Name pre-B-cell leukemia homeobox 3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000341990
InnateDB Gene IDBG-85327 (PBX3)
Protein Structure
UniProt Annotation
Function Transcriptional activator that binds the sequence 5'- ATCAATCAA-3'.
Subcellular Localization Nucleus {ECO:0000305}.
Disease Associations
Tissue Specificity Ubiquitously expressed.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007387 anterior compartment pattern formation
GO:0007388 posterior compartment specification
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR001356 Homeobox domain
IPR005542 PBX
IPR009057 Homeodomain-like
PFAM PF00046
PF03792
PRINTS
PIRSF
SMART SM00389
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P40426
PhosphoSite PhosphoSite-P40426
TrEMBL U3KQA2
UniProt Splice Variant
Entrez Gene 5090
UniGene Hs.428027
RefSeq XP_006717195
HUGO HGNC:8634
OMIM 176312
CCDS
HPRD 15938
IMGT
EMBL AF355141 AF355142 AK289376 AK309713 AL358074 AL445186 AL627303 BC094883 X59841
GenPept AAH94883 AAL09477 AAL09478 BAF82065 CAA42502 CAH73695 CAI40243 CAI40244 CAI40245

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca