InnateDB Protein
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IDBP-85586.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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HOGA1
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Protein Name
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4-hydroxy-2-oxoglutarate aldolase 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000359680
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InnateDB Gene
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IDBG-407576 (HOGA1)
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Protein Structure
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Function |
Catalyzes the final step in the metabolic pathway of hydroxyproline. {ECO:0000269PubMed:20797690, ECO:0000269PubMed:21998747}.
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Subcellular Localization |
Mitochondrion {ECO:0000250}.
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Disease Associations |
Hyperoxaluria primary 3 (HP3) [MIM:613616]: A disorder phenotypically similar to hyperoxaluria type 1 and type 2. It is characterized by increase in urinary oxalate excretion and mild glycolic aciduria. Clinical manifestations include calcium oxalate urolithiasis, hematuria, pain, and/or urinary tract infection. {ECO:0000269PubMed:20797690}. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR002220
DapA-like
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PFAM |
PF00701
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PRINTS |
PR00146
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PIRSF |
PIRSF001365
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q86XE5
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
112817
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UniGene |
Hs.180346
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RefSeq |
NP_612422
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HUGO |
HGNC:25155
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OMIM |
613597
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CCDS |
CCDS7467
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HPRD |
12584
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IMGT |
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EMBL |
AJ312051
AK289440
AL355315
BC011916
BC045550
BC057821
CH471066
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GenPept |
AAH11916
AAH45550
AAH57821
BAF82129
CAC84901
CAI15454
CAI15455
CAI15457
EAW49912
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