InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HOGA1

Summary

InnateDB Protein

IDBP-85588.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HOGA1

Protein Name

4-hydroxy-2-oxoglutarate aldolase 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000359681

InnateDB Gene

IDBG-407576 (HOGA1)

Protein Structure

UniProt Annotation

Function

Catalyzes the final step in the metabolic pathway of hydroxyproline. {ECO:0000269PubMed:20797690, ECO:0000269PubMed:21998747}.

Subcellular Localization

Mitochondrion {ECO:0000250}.

Disease Associations

Hyperoxaluria primary 3 (HP3) [MIM:613616]: A disorder phenotypically similar to hyperoxaluria type 1 and type 2. It is characterized by increase in urinary oxalate excretion and mild glycolic aciduria. Clinical manifestations include calcium oxalate urolithiasis, hematuria, pain, and/or urinary tract infection. {ECO:0000269PubMed:20797690}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008700	4-hydroxy-2-oxoglutarate aldolase activity
GO:0016829	lyase activity
GO:0042803	protein homodimerization activity

Biological Process

GO:0008152	metabolic process
GO:0009436	glyoxylate catabolic process
GO:0019470	4-hydroxyproline catabolic process
GO:0033609	oxalate metabolic process
GO:0042866	pyruvate biosynthetic process
GO:0046487	glyoxylate metabolic process