InnateDB Protein
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IDBP-8564.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CNOT7
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Protein Name
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CCR4-NOT transcription complex, subunit 7
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000355279
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InnateDB Gene
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IDBG-8558 (CNOT7)
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Protein Structure
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Function |
Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti- proliferative activity. {ECO:0000269PubMed:19605561, ECO:0000269PubMed:20065043, ECO:0000269PubMed:20634287, ECO:0000269PubMed:23236473}.
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Subcellular Localization |
Nucleus. Cytoplasm, P-body {ECO:0000250}. Note=NANOS2 promotes its localization to P-body. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 47 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated |
Total |
47
[view]
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Protein-Protein |
46
[view]
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Protein-DNA |
0
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Protein-RNA |
1
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
8 [view]
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Molecular Function |
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Biological Process |
GO:0000288
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nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
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GO:0000289
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nuclear-transcribed mRNA poly(A) tail shortening
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GO:0000290
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deadenylation-dependent decapping of nuclear-transcribed mRNA
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GO:0005975
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carbohydrate metabolic process
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GO:0006351
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transcription, DNA-templated
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GO:0006417
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regulation of translation
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GO:0007165
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signal transduction
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GO:0008284
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positive regulation of cell proliferation
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GO:0008285
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negative regulation of cell proliferation
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GO:0010467
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gene expression
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GO:0016070
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RNA metabolic process
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GO:0016071
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mRNA metabolic process
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GO:0031047
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gene silencing by RNA
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GO:0033962
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cytoplasmic mRNA processing body assembly
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GO:0035195
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gene silencing by miRNA
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GO:0043928
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exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
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GO:0045944
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positive regulation of transcription from RNA polymerase II promoter
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GO:0060213
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positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
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GO:0090503
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RNA phosphodiester bond hydrolysis, exonucleolytic
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GO:1900153
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positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
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Cellular Component |
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PDB ID |
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InterPro |
IPR006941
Ribonuclease CAF1
IPR012337
Ribonuclease H-like domain
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PFAM |
PF04857
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9UIV1
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PhosphoSite |
PhosphoSite-Q9UIV1
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TrEMBL |
E5RJE0
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UniProt Splice Variant |
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Entrez Gene |
29883
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UniGene |
Hs.711543
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RefSeq |
NP_037486
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HUGO |
HGNC:14101
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OMIM |
604913
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CCDS |
CCDS6000
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HPRD |
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IMGT |
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EMBL |
AC091050
AF086915
AK021808
AK023466
BC060852
BC070187
CH471080
L46722
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GenPept |
AAF01500
AAH60852
AAH70187
AAP97145
BAG51053
BAG51197
EAW63820
EAW63821
EAW63822
EAW63823
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