Version 5.4
Homo sapiens Protein: ANGPTL2
Summary
InnateDB Protein IDBP-85647.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ANGPTL2
Protein Name angiopoietin-like 2
Synonyms ARP2; HARP;
Species Homo sapiens
Ensembl Protein ENSP00000362524
InnateDB Gene IDBG-85645 (ANGPTL2)
Protein Structure
UniProt Annotation
Function Induces sprouting in endothelial cells through an autocrine and paracrine action.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity Widely expressed in heart, small intestine, spleen and stomach. Also found in lower levels in colon, ovary, adrenal gland, skeletal muscle and in prostate.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
Biological Process
GO:0007275 multicellular organismal development
Cellular Component
GO:0005615 extracellular space
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
PFAM PF00147
PRINTS
PIRSF
SMART SM00186
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UKU9
PhosphoSite PhosphoSite-Q9UKU9
TrEMBL Q8NCH7
UniProt Splice Variant
Entrez Gene 23452
UniGene Hs.653262
RefSeq NP_036230
HUGO HGNC:490
OMIM 605001
CCDS CCDS6868
HPRD 05415
IMGT
EMBL AF125175 AK074726 AK075026 AL356862 AY358274 BC012368 CH471090
GenPept AAD55357 AAH12368 AAQ88641 BAC11164 BAC11358 CAI39725 EAW87649 EAW87651 EAW87652

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca