Version 5.4
| Homo sapiens Protein: DNAH8 | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-85898.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | DNAH8 | ||||||||
| Protein Name | dynein, axonemal, heavy chain 8 | ||||||||
| Synonyms | ATPase; hdhc9; | ||||||||
| Species | Homo sapiens | ||||||||
| Ensembl Protein | ENSP00000352312 | ||||||||
| InnateDB Gene | IDBG-85894 (DNAH8) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity). {ECO:0000250}. | ||||||||
| Subcellular Localization | Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250}. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | |||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | |||||||||
| InterPro |
IPR003593
AAA+ ATPase domain IPR004273 Dynein heavy chain domain IPR011704 ATPase, dynein-related, AAA domain IPR013594 Dynein heavy chain, domain-1 IPR013602 Dynein heavy chain, domain-2 IPR027417 P-loop containing nucleoside triphosphate hydrolase |
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| PFAM |
PF03028
PF07728 PF08385 PF08393 |
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| PRINTS | |||||||||
| PIRSF | |||||||||
| SMART |
SM00382
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| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | Q96JB1 | ||||||||
| PhosphoSite | PhosphoSite-Q96JB1 | ||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 1769 | ||||||||
| UniGene | Hs.520106 | ||||||||
| RefSeq | |||||||||
| HUGO | HGNC:2952 | ||||||||
| OMIM | 603337 | ||||||||
| CCDS | |||||||||
| HPRD | 04515 | ||||||||
| IMGT | |||||||||
| EMBL | AF356519 AJ132091 AL034345 AL035555 AL035690 AL353700 AL391415 Z83806 | ||||||||
| GenPept | AAK60620 CAA10564 CAB06060 CAI19769 CAI19770 CAI19819 CAI19821 CAI19822 CAI20292 CAI20293 CAI20294 CAI21587 CAI21588 CAI42433 CAI42434 CAI42435 CAI42436 | ||||||||