InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GLP1R

Summary

InnateDB Protein

IDBP-86120.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GLP1R

Protein Name

glucagon-like peptide 1 receptor

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000362353

InnateDB Gene

IDBG-86118 (GLP1R)

Protein Structure

UniProt Annotation

Function

This is a receptor for glucagon-like peptide 1. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 80 experimentally validated interaction(s) in this database.

Experimentally validated
Total	80 [view]
Protein-Protein	80 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0004967	glucagon receptor activity

Biological Process

GO:0006112	energy reserve metabolic process
GO:0006950	response to stress
GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007190	activation of adenylate cyclase activity
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007611	learning or memory
GO:0008016	regulation of heart contraction
GO:0019933	cAMP-mediated signaling
GO:0044281	small molecule metabolic process
GO:0050796	regulation of insulin secretion
GO:0071377	cellular response to glucagon stimulus

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000832 GPCR, family 2, secretin-like
IPR001749 GPCR, family 2, gastric inhibitory polypeptide receptor
IPR001879 GPCR, family 2, extracellular hormone receptor domain
IPR003290 GPCR, family 2, glucagon-like peptide-1/glucagon receptor
IPR003292 GPCR, family 2, glucagon-like peptide-1 receptor
IPR017981 GPCR, family 2-like

PFAM

PF00002
PF02793

PRINTS

PR00249
PR01129
PR01353
PR01355

PIRSF

SMART

SM00008

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt