InnateDB Protein
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IDBP-86251.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CPN1
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Protein Name
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carboxypeptidase N, polypeptide 1
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Synonyms
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CPN; SCPN;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000359446
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InnateDB Gene
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IDBG-86249 (CPN1)
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Protein Structure
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Function |
Protects the body from potent vasoactive and inflammatory peptides containing C-terminal Arg or Lys (such as kinins or anaphylatoxins) which are released into the circulation.
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Subcellular Localization |
Secreted, extracellular space.
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Disease Associations |
Carboxypeptidase N deficiency (CPND) [MIM:212070]: Patients affected present some combination of angioedema or chronic urticaria, as well as hay fever or asthma, and have also slightly depressed serum carboxy peptidase N, suggestive of autosomal recessive inheritance of this disorder. {ECO:0000269PubMed:12560874}. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
Synthesized in the liver and secreted in plasma.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
3
[view]
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Protein-Protein |
3
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000834
Peptidase M14, carboxypeptidase A
IPR008969
Carboxypeptidase-like, regulatory domain
IPR021259
Protein of unknown function DUF2817
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PFAM |
PF00246
PF10994
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PRINTS |
PR00765
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PIRSF |
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SMART |
SM00631
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TIGRFAMs |
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Modification |
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SwissProt |
P15169
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PhosphoSite |
PhosphoSite-P15169
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TrEMBL |
B1AP58
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UniProt Splice Variant |
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Entrez Gene |
1369
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UniGene |
Hs.2246
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RefSeq |
NP_001299
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HUGO |
HGNC:2312
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OMIM |
603103
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CCDS |
CCDS7486
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HPRD |
09120
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IMGT |
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EMBL |
AK313972
AL441886
BC027897
CH471066
X14329
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GenPept |
AAH27897
BAG36687
CAA32507
EAW49848
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