InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: WNT8B

Summary

InnateDB Protein

IDBP-86501.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

WNT8B

Protein Name

wingless-type MMTV integration site family, member 8B

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000340677

InnateDB Gene

IDBG-86499 (WNT8B)

Protein Structure

UniProt Annotation

Function

Ligand for members of the frizzled family of seven transmembrane receptors. May play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus. {ECO:0000269PubMed:9536085}.

Subcellular Localization

Secreted, extracellular space, extracellular matrix.

Disease Associations

Tissue Specificity

Expression is restricted to the brain, and more specifically to the forebrain. {ECO:0000269PubMed:9536085}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005109	frizzled binding

Biological Process

GO:0007165	signal transduction
GO:0007275	multicellular organismal development
GO:0007369	gastrulation
GO:0007399	nervous system development
GO:0010628	positive regulation of gene expression
GO:0010629	negative regulation of gene expression
GO:0016055	Wnt signaling pathway
GO:0030182	neuron differentiation
GO:0032355	response to estradiol
GO:0032526	response to retinoic acid
GO:0045165	cell fate commitment
GO:0048263	determination of dorsal identity
GO:0071300	cellular response to retinoic acid