InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FPGS

Summary

InnateDB Protein

IDBP-86512.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FPGS

Protein Name

folylpolyglutamate synthase

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000362322

InnateDB Gene

IDBG-86502 (FPGS)

Protein Structure

UniProt Annotation

Function

Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. Unsubstitued reduced folates are the preferred substrates. Metabolizes methotrexate (MTX) to polyglutamates. {ECO:0000269PubMed:8408018, ECO:0000269PubMed:8408019, ECO:0000269PubMed:8408021, ECO:0000269PubMed:8662720}.

Subcellular Localization

Isoform 1: Mitochondrion inner membrane. Mitochondrion matrix.Isoform 2: Cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004326	tetrahydrofolylpolyglutamate synthase activity
GO:0005524	ATP binding
GO:0016874	ligase activity

Biological Process

GO:0006139	nucleobase-containing compound metabolic process
GO:0006730	one-carbon metabolic process
GO:0006766	vitamin metabolic process
GO:0006767	water-soluble vitamin metabolic process
GO:0009058	biosynthetic process
GO:0009396	folic acid-containing compound biosynthetic process
GO:0044281	small molecule metabolic process
GO:0046655	folic acid metabolic process
GO:0046901	tetrahydrofolylpolyglutamate biosynthetic process