InnateDB Protein
|
IDBP-86512.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
FPGS
|
Protein Name
|
folylpolyglutamate synthase
|
Synonyms
|
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000362322
|
InnateDB Gene
|
IDBG-86502 (FPGS)
|
Protein Structure
|
|
Function |
Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. Unsubstitued reduced folates are the preferred substrates. Metabolizes methotrexate (MTX) to polyglutamates. {ECO:0000269PubMed:8408018, ECO:0000269PubMed:8408019, ECO:0000269PubMed:8408021, ECO:0000269PubMed:8662720}.
|
Subcellular Localization |
Isoform 1: Mitochondrion inner membrane. Mitochondrion matrix.Isoform 2: Cytoplasm.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
|
Protein-Protein |
1
[view]
|
Protein-DNA |
1
[view]
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR001645
Folylpolyglutamate synthetase
IPR004101
Mur ligase, C-terminal
IPR013221
Mur ligase, central
|
PFAM |
PF02875
PF08245
|
PRINTS |
|
PIRSF |
PIRSF001563
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q05932
|
PhosphoSite |
PhosphoSite-Q05932
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
2356
|
UniGene |
Hs.335084
|
RefSeq |
NP_001018088
|
HUGO |
HGNC:3824
|
OMIM |
136510
|
CCDS |
CCDS35149
|
HPRD |
00642
|
IMGT |
|
EMBL |
AH003340
AH006037
AK056920
AK295309
AL162586
BC064393
M98045
U14939
|
GenPept |
AAA35852
AAA85815
AAA87568
AAC13871
AAH64393
BAG51826
BAH12029
CAI39770
CAI39773
|
|
|