Version 5.4
Homo sapiens Protein: TPSAB1
Summary
InnateDB Protein IDBP-8675.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TPSAB1
Protein Name tryptase alpha/beta 1
Synonyms TPS1; TPS2; TPSB1;
Species Homo sapiens
Ensembl Protein ENSP00000343577
InnateDB Gene IDBG-8673 (TPSAB1)
Protein Structure
UniProt Annotation
Function Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. {ECO:0000250}.
Subcellular Localization Secreted. Note=Released from the secretory granules upon mast cell activation. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
GO:0005515 protein binding
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0006952 defense response
GO:0022617 extracellular matrix disassembly
GO:0030198 extracellular matrix organization
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0031012 extracellular matrix
Protein Structure and Domains
PDB ID
InterPro IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR009003 Trypsin-like cysteine/serine peptidase domain
PFAM PF00089
PRINTS PR00722
PIRSF
SMART SM00020
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q15661
PhosphoSite PhosphoSite-Q15661
TrEMBL
UniProt Splice Variant
Entrez Gene 7177
UniGene Hs.592982
RefSeq NP_003285
HUGO HGNC:12019
OMIM 191081
CCDS CCDS10431
HPRD 01849
IMGT
EMBL AC120498 AF098328 AF099143 AF099144 AF099145 AF099146 AF206665 AF206666 AF206667 BC029356 BC074974 FJ931116 FJ931117 FJ931118 FJ931120 M30038 M33491 M33492 M33493 M33494 M37488 S55551
GenPept AAA36778 AAA36779 AAA36780 AAA51843 AAA86934 AAC83172 AAD13876 AAD17846 AAD17857 AAD17858 AAD17859 AAD17860 AAG35695 AAG35696 AAG35697 AAH29356 AAH74974 ACZ98910 ACZ98911 ACZ98912 ACZ98913

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca