Version 5.4
Homo sapiens Protein: TNFRSF6B
Summary
InnateDB Protein IDBP-86855.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TNFRSF6B
Protein Name tumor necrosis factor receptor superfamily, member 6b, decoy
Synonyms DCR3; DJ583P15.1.1; M68; M68E; TR6;
Species Homo sapiens
Ensembl Protein ENSP00000359013
InnateDB Gene IDBG-402658 (TNFRSF6B)
Protein Structure
UniProt Annotation
Function Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis. {ECO:0000269PubMed:21300286}.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity Detected in fetal lung, brain and liver. Detected in adult stomach, spinal cord, lymph node, trachea, spleen, colon and lung. Highly expressed in several primary tumors from colon, stomach, rectum, esophagus and in SW480 colon carcinoma cells.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005515 protein binding
Biological Process
GO:0006915 apoptotic process
GO:0043066 negative regulation of apoptotic process
Cellular Component
GO:0005615 extracellular space
Protein Structure and Domains
PDB ID
InterPro IPR001368 TNFR/NGFR cysteine-rich region
PFAM PF00020
PRINTS
PIRSF
SMART SM00208
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O95407
PhosphoSite PhosphoSite-O95407
TrEMBL H0UI95
UniProt Splice Variant
Entrez Gene 8771
UniGene
RefSeq NP_003814
HUGO HGNC:11921
OMIM 603361
CCDS CCDS13532
HPRD 04527
IMGT
EMBL AF104419 AF134240 AF217793 AF217794 AF217796 AL121845 AY358279 BC017065 BC034349 CH471077
GenPept AAD03056 AAD29688 AAF33685 AAF33686 AAF35244 AAH17065 AAH34349 AAQ88646 CAC03668 EAW75247 EAW75248

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca