InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: UBR2

Summary

InnateDB Protein

IDBP-87243.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UBR2

Protein Name

ubiquitin protein ligase E3 component n-recognin 2

Synonyms

bA49A4.1; C6orf133; dJ242G1.1; dJ392M17.3;

Species

Homo sapiens

Ensembl Protein

ENSP00000361992

InnateDB Gene

IDBG-87239 (UBR2)

Protein Structure

UniProt Annotation

Function

E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Plays a critical role in chromatin inactivation and chromosome-wide transcriptional silencing during meiosis via ubiquitination of histone H2A. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth. {ECO:0000269PubMed:15548684, ECO:0000269PubMed:20298436, ECO:0000269PubMed:20835242}.

Subcellular Localization

Nucleus {ECO:0000250}. Note=Associated with chromatin during meiosis.

Disease Associations

Tissue Specificity

Broadly expressed, with highest levels in skeletal muscle, kidney and pancreas. Present in acinar cells of the pancreas (at protein level). {ECO:0000269PubMed:15548684, ECO:0000269PubMed:16311597}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0070728	leucine binding

Biological Process

GO:0006342	chromatin silencing
GO:0030163	protein catabolic process
GO:0032007	negative regulation of TOR signaling
GO:0033522	histone H2A ubiquitination
GO:0071233	cellular response to leucine

Cellular Component

GO:0005634	nucleus
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR003126 Zinc finger, N-recognin
IPR003769 Adaptor protein ClpS, core
IPR013993 Zinc finger, N-recognin, metazoa
IPR014719 Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like

PFAM

PF02207
PF02617

PRINTS

PIRSF

SMART

SM00396

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8IWV8