InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GNMT

Summary

InnateDB Protein

IDBP-87451.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GNMT

Protein Name

glycine N-methyltransferase

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000361894

InnateDB Gene

IDBG-87449 (GNMT)

Protein Structure

UniProt Annotation

Function

Catalyzes the methylation of glycine by using S- adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine. {ECO:0000269PubMed:15340920, ECO:0000269PubMed:17660255}.

Subcellular Localization

Cytoplasm.

Disease Associations

Glycine N-methyltransferase deficiency (GNMT deficiency) [MIM:606664]: The only clinical abnormalities in patients with this deficiency are mild hepatomegaly and chronic elevation of serum transaminases. {ECO:0000269PubMed:11810299, ECO:0000269PubMed:14739680}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Abundant in liver.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.

Experimentally validated
Total	15 [view]
Protein-Protein	14 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005542	folic acid binding
GO:0008168	methyltransferase activity
GO:0016594	glycine binding
GO:0017174	glycine N-methyltransferase activity

Biological Process

GO:0005977	glycogen metabolic process
GO:0006111	regulation of gluconeogenesis
GO:0006464	cellular protein modification process
GO:0006555	methionine metabolic process
GO:0006730	one-carbon metabolic process
GO:0008152	metabolic process
GO:0032259	methylation
GO:0046500	S-adenosylmethionine metabolic process
GO:0051289	protein homotetramerization

Cellular Component

GO:0005737

cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR013216 Methyltransferase type 11
IPR013217 Methyltransferase type 12
IPR014369 Glycine/Sarcosine N-methyltransferase
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like

PFAM

PF08241
PF08242

PRINTS

PIRSF

PIRSF000385

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q14749