InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MGEA5

Summary

InnateDB Protein

IDBP-87482.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MGEA5

Protein Name

meningioma expressed antigen 5 (hyaluronidase)

Synonyms

MEA5; NCOAT; OGA;

Species

Homo sapiens

Ensembl Protein

ENSP00000354850

InnateDB Gene

IDBG-87480 (MGEA5)

Protein Structure

UniProt Annotation

Function

Cleaves GlcNAc but not GalNAc from glycopeptides. Can use p-nitrophenyl-beta-GlcNAc as substrate but not p-nitrophenyl- beta-GalNAc or p-nitrophenyl-alpha-GlcNAc. Possesses hyaluronidase activity. Acetylates 'Lys-8' of histone H4 and 'Lys-14' of histone H3. {ECO:0000269PubMed:11148210, ECO:0000269PubMed:11788610}.

Subcellular Localization

Isoform 3: Nucleus.Isoform 1: Cytoplasm.

Disease Associations

Tissue Specificity

Ubiquitous. Shows highest expression in the brain, placenta and pancreas. {ECO:0000269PubMed:11148210, ECO:0000269PubMed:11341771}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	32 [view]
Protein-Protein	28 [view]
Protein-DNA	3 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004402	histone acetyltransferase activity
GO:0004415	hyalurononglucosaminidase activity

Biological Process

GO:0006044	N-acetylglucosamine metabolic process
GO:0006516	glycoprotein catabolic process
GO:0006612	protein targeting to membrane
GO:0007568	aging
GO:0010524	positive regulation of calcium ion transport into cytosol
GO:0010616	negative regulation of cardiac muscle adaptation
GO:0031343	positive regulation of cell killing
GO:0032024	positive regulation of insulin secretion
GO:0043243	positive regulation of protein complex disassembly
GO:0045862	positive regulation of proteolysis
GO:0046060	dATP metabolic process
GO:0046326	positive regulation of glucose import
GO:0048545	response to steroid hormone
GO:0051054	positive regulation of DNA metabolic process
GO:0051901	positive regulation of mitochondrial depolarization
GO:0051928	positive regulation of calcium ion transport
GO:0060051	negative regulation of protein glycosylation
GO:0060124	positive regulation of growth hormone secretion
GO:0070265	necrotic cell death