InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PTK7

Summary

InnateDB Protein

IDBP-87776.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PTK7

Protein Name

PTK7 protein tyrosine kinase 7

Synonyms

CCK-4; CCK4;

Species

Homo sapiens

Ensembl Protein

ENSP00000326029

InnateDB Gene

IDBG-87768 (PTK7)

Protein Structure

UniProt Annotation

Function

Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis. {ECO:0000269PubMed:18471990, ECO:0000269PubMed:20558616, ECO:0000269PubMed:20837484, ECO:0000269PubMed:21103379, ECO:0000269PubMed:21132015}.

Subcellular Localization

Membrane {ECO:0000269PubMed:20837484}; Single-pass type I membrane protein {ECO:0000269PubMed:20837484}. Cell junction {ECO:0000269PubMed:20837484}. Note=Colocalizes with MMP14 at cell junctions. Also localizes at the leading edge of migrating cells.

Disease Associations

Tissue Specificity

Highly expressed in lung, liver, pancreas, kidney, placenta and melanocytes. Weakly expressed in thyroid gland, ovary, brain, heart and skeletal muscle. Also expressed in erythroleukemia cells. But not expressed in colon.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	3 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004714	transmembrane receptor protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0007155	cell adhesion
GO:0007165	signal transduction
GO:0010976	positive regulation of neuron projection development
GO:0016477	cell migration
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0031532	actin cytoskeleton reorganization
GO:0060070	canonical Wnt signaling pathway
GO:0071300	cellular response to retinoic acid

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0005911	cell-cell junction

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR011009 Protein kinase-like domain
IPR013098 Immunoglobulin I-set
IPR013151 Immunoglobulin
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF07679
PF00047

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00408
SM00409
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt