Homo sapiens Protein: PTK7 | |||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Summary | |||||||||||||||||||
InnateDB Protein | IDBP-87778.7 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | PTK7 | ||||||||||||||||||
Protein Name | PTK7 protein tyrosine kinase 7 | ||||||||||||||||||
Synonyms | CCK-4; CCK4; | ||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Protein | ENSP00000230418 | ||||||||||||||||||
InnateDB Gene | IDBG-87768 (PTK7) | ||||||||||||||||||
Protein Structure | |||||||||||||||||||
UniProt Annotation | |||||||||||||||||||
Function | Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis. {ECO:0000269PubMed:18471990, ECO:0000269PubMed:20558616, ECO:0000269PubMed:20837484, ECO:0000269PubMed:21103379, ECO:0000269PubMed:21132015}. | ||||||||||||||||||
Subcellular Localization | Membrane {ECO:0000269PubMed:20837484}; Single-pass type I membrane protein {ECO:0000269PubMed:20837484}. Cell junction {ECO:0000269PubMed:20837484}. Note=Colocalizes with MMP14 at cell junctions. Also localizes at the leading edge of migrating cells. | ||||||||||||||||||
Disease Associations | |||||||||||||||||||
Tissue Specificity | Highly expressed in lung, liver, pancreas, kidney, placenta and melanocytes. Weakly expressed in thyroid gland, ovary, brain, heart and skeletal muscle. Also expressed in erythroleukemia cells. But not expressed in colon. | ||||||||||||||||||
Comments | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
|
||||||||||||||||||
Gene Ontology | |||||||||||||||||||
Molecular Function |
|
||||||||||||||||||
Biological Process |
|
||||||||||||||||||
Cellular Component |
|
||||||||||||||||||
Protein Structure and Domains | |||||||||||||||||||
PDB ID | |||||||||||||||||||
InterPro |
IPR003598
Immunoglobulin subtype 2 IPR003599 Immunoglobulin subtype IPR007110 Immunoglobulin-like domain IPR013098 Immunoglobulin I-set IPR013106 Immunoglobulin V-set domain IPR013151 Immunoglobulin |
||||||||||||||||||
PFAM |
PF07679
PF07686 PF00047 |
||||||||||||||||||
PRINTS | |||||||||||||||||||
PIRSF | |||||||||||||||||||
SMART |
SM00408
SM00409 |
||||||||||||||||||
TIGRFAMs | |||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||
Modification | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | Q13308 | ||||||||||||||||||
PhosphoSite | PhosphoSite-Q13308 | ||||||||||||||||||
TrEMBL | F8WDG7 | ||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 5754 | ||||||||||||||||||
UniGene | Hs.90572 | ||||||||||||||||||
RefSeq | |||||||||||||||||||
HUGO | HGNC:9618 | ||||||||||||||||||
OMIM | 601890 | ||||||||||||||||||
CCDS | |||||||||||||||||||
HPRD | 03534 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AF447157 AF447158 AF447162 AF447164 AF447167 AF447170 AF447171 AF447173 AF447174 AF447175 AF447176 AF531868 AF531869 AF531870 AF531871 AF531872 AK291016 AK292589 AK296953 AL355385 BC071557 CH471081 U33635 U40271 | ||||||||||||||||||
GenPept | AAA87565 AAC50484 AAH71557 AAL39062 AAN04862 AAN04863 AAN04864 AAN04865 AAN04866 BAF83705 BAF85278 BAH12463 CAI13783 EAX04154 EAX04155 EAX04156 EAX04158 EAX04160 | ||||||||||||||||||