InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RGS19

Summary

InnateDB Protein

IDBP-87818.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RGS19

Protein Name

regulator of G-protein signaling 19

Synonyms

GAIP; RGSGAIP;

Species

Homo sapiens

Ensembl Protein

ENSP00000333194

InnateDB Gene

IDBG-87816 (RGS19)

Protein Structure

UniProt Annotation

Function

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein.

Subcellular Localization

Membrane; Lipid-anchor.

Disease Associations

Tissue Specificity

Highest expression in lung. Placenta, liver and heart also express high levels of GAIP.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005096	GTPase activator activity
GO:0005515	protein binding

Biological Process

GO:0006914	autophagy
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007264	small GTPase mediated signal transduction
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
GO:0038032	termination of G-protein coupled receptor signaling pathway
GO:0043547	positive regulation of GTPase activity