InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CUL9

Summary

InnateDB Protein

IDBP-87856.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CUL9

Protein Name

cullin 9

Synonyms

H7AP1; PARC;

Species

Homo sapiens

Ensembl Protein

ENSP00000252050

InnateDB Gene

IDBG-87852 (CUL9)

Protein Structure

UniProt Annotation

Function

Core component of a Cul9-RING ubiquitin-protein ligase complex, a complex that mediates ubiquitination and subsequent degradation of BIRC5 and is required to maintain microtubule dynamics and genome integrity. Acts downstream of the 3M complex, which inhibits CUL9 activity, leading to prevent ubiquitination of BIRC5 (PubMed:24793696). Cytoplasmic anchor protein in p53/TP53- associated protein complex. Regulates the subcellular localization of p53/TP53 and subsequent function (PubMed:12526791, PubMed:17332328). {ECO:0000269PubMed:12526791, ECO:0000269PubMed:17332328, ECO:0000269PubMed:24793696}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:12526791}.

Disease Associations

Tissue Specificity

Ubiquitously expressed in all tissues with highest expression in testis brain and kidney. {ECO:0000269PubMed:12526791}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008270	zinc ion binding
GO:0031625	ubiquitin protein ligase binding

Biological Process

GO:0000226	microtubule cytoskeleton organization
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0007088	regulation of mitosis
GO:0016567	protein ubiquitination

Cellular Component

GO:0005737	cytoplasm
GO:0031461	cullin-RING ubiquitin ligase complex

Protein Structure and Domains

PDB ID

InterPro

IPR001373 Cullin, N-terminal
IPR001841 Zinc finger, RING-type
IPR002867 Zinc finger, C6HC-type
IPR004939 Anaphase-promoting complex, subunit 10/DOC domain
IPR008979 Galactose-binding domain-like
IPR009060 UBA-like
IPR016024 Armadillo-type fold
IPR016158 Cullin homology
IPR019559 Cullin protein, neddylation domain
IPR021097 CPH domain

PFAM