InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SPTAN1

Summary

InnateDB Protein

IDBP-88284.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SPTAN1

Protein Name

spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)

Synonyms

EIEE5; NEAS; SPTA2;

Species

Homo sapiens

Ensembl Protein

ENSP00000361816

InnateDB Gene

IDBG-88280 (SPTAN1)

Protein Structure

UniProt Annotation

Function

Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.

Subcellular Localization

Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Note=Expressed along the cell membrane in podocytes and presumptive tubule cells during glomerulogenesis and is expressed along lateral cell margins in tubule cells. {ECO:0000250}.

Disease Associations

Epileptic encephalopathy, early infantile, 5 (EIEE5) [MIM:613477]: A disorder characterized by seizures associated with hypsarrhythmia, profound mental retardation with lack of visual attention and speech development, as well as spastic quadriplegia. {ECO:0000269PubMed:20493457}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 147 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	147 [view]
Protein-Protein	146 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005200	structural constituent of cytoskeleton
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005516	calmodulin binding

Biological Process

GO:0006915	apoptotic process
GO:0006921	cellular component disassembly involved in execution phase of apoptosis
GO:0007411	axon guidance
GO:0051693	actin filament capping

Cellular Component

GO:0005829	cytosol
GO:0008091	spectrin
GO:0015630	microtubule cytoskeleton
GO:0016020	membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001452 SH3 domain
IPR002017 Spectrin repeat
IPR002048 EF-hand domain
IPR011511 Variant SH3 domain
IPR013315 Spectrin alpha chain, SH3 domain
IPR014837 EF-hand, Ca insensitive
IPR018159 Spectrin/alpha-actinin

PFAM