InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: INA

Summary

InnateDB Protein

IDBP-88398.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

INA

Protein Name

internexin neuronal intermediate filament protein, alpha

Synonyms

NEF5; NF-66; TXBP-1;

Species

Homo sapiens

Ensembl Protein

ENSP00000358865

InnateDB Gene

IDBG-88396 (INA)

Protein Structure

UniProt Annotation

Function

Class-IV neuronal intermediate filament that is able to self-assemble. It is involved in the morphogenesis of neurons. It may form an independent structural network without the involvement of other neurofilaments or it may cooperate with NF-L to form the filamentous backbone to which NF-M and NF-H attach to form the cross-bridges.

Subcellular Localization

Disease Associations

Tissue Specificity

Found predominantly in adult CNS.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005198	structural molecule activity
GO:0005200	structural constituent of cytoskeleton
GO:0005515	protein binding

Biological Process

GO:0021762	substantia nigra development
GO:0030154	cell differentiation
GO:0045104	intermediate filament cytoskeleton organization
GO:0060052	neurofilament cytoskeleton organization