InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TAF5

Summary

InnateDB Protein

IDBP-88425.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TAF5

Protein Name

TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa

Synonyms

TAF2D; TAFII100;

Species

Homo sapiens

Ensembl Protein

ENSP00000358854

InnateDB Gene

IDBG-88423 (TAF5)

Protein Structure

UniProt Annotation

Function

TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TAFs components-TIIFD are essential for mediating regulation of RNA polymerase transcription. TAF5/TAFII100 interacts strongly with the histone H4-related TAF6/TAFII80 and the histone H3-related TAF9/TAFII31, as well as a stable complex comprised of both TAF5/TAFII80 and TAF6/TAFII31. Apparently weaker interactions of TAF5/TAFII100 with TBP, TAF1/TAFII250, TAF11/TAFII28, and TAF12/TAFII20, but not TAF7/TAFII55, also have been observed.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 46 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	46 [view]
Protein-Protein	46 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0004402	histone acetyltransferase activity
GO:0005515	protein binding
GO:0044212	transcription regulatory region DNA binding
GO:0046983	protein dimerization activity

Biological Process

GO:0006352	DNA-templated transcription, initiation
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006368	transcription elongation from RNA polymerase II promoter
GO:0010467	gene expression
GO:0016032	viral process
GO:0016568	chromatin modification
GO:0016573	histone acetylation

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005669	transcription factor TFIID complex
GO:0015629	actin cytoskeleton
GO:0033276	transcription factor TFTC complex
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

InterPro

IPR001680 WD40 repeat
IPR006594 LisH dimerisation motif
IPR007582 TFIID subunit, WD40-associated region
IPR017986 WD40-repeat-containing domain
IPR020472 G-protein beta WD-40 repeat

PFAM

PF00400
PF04494

PRINTS

PR00320

PIRSF

SMART

SM00320
SM00667

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt