InnateDB Protein
|
IDBP-8865.5
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
MEOX2
|
Protein Name
|
mesenchyme homeobox 2
|
Synonyms
|
GAX; MOX2;
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000262041
|
InnateDB Gene
|
IDBG-8863 (MEOX2)
|
Protein Structure
|
|
Function |
Role in mesoderm induction and its earliest regional specification, somitogenesis, and myogenic and sclerotomal differentiation. May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle (By similarity). {ECO:0000250}.
|
Subcellular Localization |
Nucleus {ECO:0000255PROSITE- ProRule:PRU00108, ECO:0000269PubMed:19266028}. Nucleus speckle {ECO:0000255PROSITE-ProRule:PRU00108, ECO:0000269PubMed:19266028}.
|
Disease Associations |
|
Tissue Specificity |
Embryo and placenta.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 40 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated |
Total |
40
[view]
|
Protein-Protein |
40
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
5 [view]
|
|
|
Molecular Function |
Accession |
GO Term |
GO:0000978
|
RNA polymerase II core promoter proximal region sequence-specific DNA binding
|
GO:0000980
|
RNA polymerase II distal enhancer sequence-specific DNA binding
|
GO:0001077
|
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
|
GO:0001205
|
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
|
GO:0003677
|
DNA binding
|
GO:0005515
|
protein binding
|
GO:0043565
|
sequence-specific DNA binding
|
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR001356
Homeobox domain
IPR009057
Homeodomain-like
IPR020479
Homeodomain, metazoa
|
PFAM |
PF00046
|
PRINTS |
PR00024
|
PIRSF |
|
SMART |
SM00389
|
TIGRFAMs |
|
Modification |
|
SwissProt |
P50222
|
PhosphoSite |
PhosphoSite-P50222
|
TrEMBL |
Q6FHY5
|
UniProt Splice Variant |
|
Entrez Gene |
4223
|
UniGene |
Hs.702298
|
RefSeq |
NP_005915
|
HUGO |
HGNC:7014
|
OMIM |
600535
|
CCDS |
CCDS34605
|
HPRD |
02760
|
IMGT |
|
EMBL |
AC004452
AC005550
AK313386
BC017021
CH236948
CR536553
L36328
X82629
|
GenPept |
AAA58497
AAC06184
AAC33152
AAH17021
BAG36184
CAA57949
CAG38790
EAL24289
|
|
|