InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MEOX2

Summary

InnateDB Protein

IDBP-8865.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MEOX2

Protein Name

mesenchyme homeobox 2

Synonyms

GAX; MOX2;

Species

Homo sapiens

Ensembl Protein

ENSP00000262041

InnateDB Gene

IDBG-8863 (MEOX2)

Protein Structure

UniProt Annotation

Function

Role in mesoderm induction and its earliest regional specification, somitogenesis, and myogenic and sclerotomal differentiation. May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00108, ECO:0000269PubMed:19266028}. Nucleus speckle {ECO:0000255PROSITE-ProRule:PRU00108, ECO:0000269PubMed:19266028}.

Disease Associations

Tissue Specificity

Embryo and placenta.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 40 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	40 [view]
Protein-Protein	40 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001205	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0001525	angiogenesis
GO:0001757	somite specification
GO:0007275	multicellular organismal development
GO:0007519	skeletal muscle tissue development
GO:0008015	blood circulation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0060021	palate development
GO:0060173	limb development
GO:0070997	neuron death