InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CRAT

Summary

InnateDB Protein

IDBP-88993.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CRAT

Protein Name

carnitine O-acetyltransferase

Synonyms

CAT1;

Species

Homo sapiens

Ensembl Protein

ENSP00000315013

InnateDB Gene

IDBG-88989 (CRAT)

Protein Structure

UniProt Annotation

Function

Carnitine acetylase is specific for short chain fatty acids. Carnitine acetylase seems to affect the flux through the pyruvate dehydrogenase complex. It may be involved as well in the transport of acetyl-CoA into mitochondria.

Subcellular Localization

Endoplasmic reticulum {ECO:0000305}. Peroxisome {ECO:0000305}. Mitochondrion inner membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Matrix side {ECO:0000305}.Isoform 1: Mitochondrion {ECO:0000305}.Isoform 2: Peroxisome {ECO:0000305}.

Disease Associations

Tissue Specificity

Mostly in skeletal muscle, less in heart, liver and pancreas, only weakly detectable in brain, placenta, lung and kidney.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	7 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004092	carnitine O-acetyltransferase activity
GO:0005102	receptor binding
GO:0016746	transferase activity, transferring acyl groups

Biological Process

GO:0006810	transport
GO:0019254	carnitine metabolic process, CoA-linked
GO:0033540	fatty acid beta-oxidation using acyl-CoA oxidase
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process