InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PGD

Summary

InnateDB Protein

IDBP-89011.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PGD

Protein Name

phosphogluconate dehydrogenase

Synonyms

6PGD;

Species

Homo sapiens

Ensembl Protein

ENSP00000270776

InnateDB Gene

IDBG-89009 (PGD)

Protein Structure

UniProt Annotation

Function

Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.

Experimentally validated
Total	36 [view]
Protein-Protein	36 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity
GO:0050661	NADP binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006098	pentose-phosphate shunt
GO:0009051	pentose-phosphate shunt, oxidative branch
GO:0019322	pentose biosynthetic process
GO:0019521	D-gluconate metabolic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005634	nucleus
GO:0005829	cytosol
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR006113 6-phosphogluconate dehydrogenase, decarboxylating
IPR006114 6-phosphogluconate dehydrogenase, C-terminal
IPR006115 6-phosphogluconate dehydrogenase, NADP-binding
IPR008927 6-phosphogluconate dehydrogenase, C-terminal-like

PFAM

PF00393
PF03446

PRINTS

PIRSF

PIRSF000109

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P52209