InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC29A1

Summary

InnateDB Protein

IDBP-89075.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC29A1

Protein Name

solute carrier family 29 (nucleoside transporters), member 1

Synonyms

ENT1;

Species

Homo sapiens

Ensembl Protein

ENSP00000360773

InnateDB Gene

IDBG-89061 (SLC29A1)

Protein Structure

UniProt Annotation

Function

Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). It is sensitive (ES) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and is sodium-independent. It has a higher affinity for adenosine. Inhibited by dipyridamole and dilazep (anticancer chemotherapeutics drugs).

Subcellular Localization

Basolateral cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Predominantly localized in the basolateral membrane in polarized MDCK cells.

Disease Associations

Tissue Specificity

Detected in erythrocytes (at protein level). Expressed in heart, brain, mammary gland, erythrocytes and placenta, and also in fetal liver and spleen. {ECO:0000269PubMed:12527552, ECO:0000269PubMed:23219802}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005337	nucleoside transmembrane transporter activity

Biological Process

GO:0006139	nucleobase-containing compound metabolic process
GO:0006810	transport
GO:0015858	nucleoside transport
GO:0055085	transmembrane transport
GO:1901642	nucleoside transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0016324	apical plasma membrane