InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TOR1B

Summary

InnateDB Protein

IDBP-89257.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TOR1B

Protein Name

torsin family 1, member B (torsin B)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000259339

InnateDB Gene

IDBG-89253 (TOR1B)

Protein Structure

UniProt Annotation

Function

May serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins. Plays a role in non-neural cells nuclear envelope and endoplasmic reticulum integrity. May have a redundant function with TOR1A in non-neural tissues. {ECO:0000269PubMed:23569223, ECO:0000269PubMed:24275647}.

Subcellular Localization

Endoplasmic reticulum lumen {ECO:0000269PubMed:15147511}. Nucleus membrane {ECO:0000269PubMed:15147511}.

Disease Associations

Tissue Specificity

Widely expressed with low levels in brain. {ECO:0000269PubMed:15147511}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016887	ATPase activity

Biological Process

GO:0006200	ATP catabolic process
GO:0006986	response to unfolded protein
GO:0007029	endoplasmic reticulum organization
GO:0051085	chaperone mediated protein folding requiring cofactor
GO:0051260	protein homooligomerization
GO:0071763	nuclear membrane organization

Cellular Component

GO:0005635	nuclear envelope
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005788	endoplasmic reticulum lumen
GO:0031965	nuclear membrane
GO:0070062	extracellular vesicular exosome