InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MAGEA1

Summary

InnateDB Protein

IDBP-89382.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAGEA1

Protein Name

melanoma antigen family A, 1 (directs expression of antigen MZ2-E)

Synonyms

CT1.1; MAGE1;

Species

Homo sapiens

Ensembl Protein

ENSP00000349085

InnateDB Gene

IDBG-89380 (MAGEA1)

Protein Structure

UniProt Annotation

Function

May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. {ECO:0000269PubMed:15316101}.

Subcellular Localization

Cytoplasm. Nucleus.

Disease Associations

Tissue Specificity

Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes. Never expressed in kidney tumors, leukemias and lymphomas.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.

Experimentally validated
Total	21 [view]
Protein-Protein	21 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042826	histone deacetylase binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0045746	negative regulation of Notch signaling pathway