InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CDC5L

Summary

InnateDB Protein

IDBP-89606.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CDC5L

Protein Name

CDC5 cell division cycle 5-like (S. pombe)

Synonyms

CDC5; CDC5-LIKE; CEF1; dJ319D22.1; PCDC5RP;

Species

Homo sapiens

Ensembl Protein

ENSP00000360532

InnateDB Gene

IDBG-89604 (CDC5L)

Protein Structure

UniProt Annotation

Function

DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. {ECO:0000269PubMed:10570151, ECO:0000269PubMed:11082045, ECO:0000269PubMed:11101529, ECO:0000269PubMed:11544257, ECO:0000269PubMed:12927788, ECO:0000269PubMed:18583928, ECO:0000269PubMed:9038199, ECO:0000269PubMed:9468527, ECO:0000269PubMed:9632794}.

Subcellular Localization

Nucleus. Nucleus speckle. Cytoplasm. Note=May shuttle between cytoplasm and nucleus.

Disease Associations

Note=A chromosomal aberration involving CDC5L is found in multicystic renal dysplasia. Translocation t(6;19)(p21;q13.1) with USF2.

Tissue Specificity

Ubiquitously expressed in both fetal and adult tissues. {ECO:0000269PubMed:9038199, ECO:0000269PubMed:9598309, ECO:0000269PubMed:9632794}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 224 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	224 [view]
Protein-Protein	223 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0019904	protein domain specific binding
GO:0044822	poly(A) RNA binding
GO:0071987	WD40-repeat domain binding

Biological Process

GO:0000398	mRNA splicing, via spliceosome
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007049	cell cycle
GO:0008380	RNA splicing

Cellular Component

GO:0000974	Prp19 complex
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0016020	membrane
GO:0016607	nuclear speck
GO:0071013	catalytic step 2 spliceosome