InnateDB Protein
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IDBP-8964.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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RBX1
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Protein Name
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ring-box 1, E3 ubiquitin protein ligase
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Synonyms
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BA554C12.1; RNF75; ROC1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000216225
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InnateDB Gene
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IDBG-8962 (RBX1)
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Protein Structure
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Function |
E3 ubiquitin ligase component of multiple cullin-RING- based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins, including proteins involved in cell cycle progression, signal transduction, transcription and transcription-coupled nucleotide excision repair. The functional specificity of the E3 ubiquitin-protein ligase complexes depends on the variable substrate recognition components. As a component of the CSA complex promotes the ubiquitination of ERCC6 resulting in proteasomal degradation. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme, like CDC34, to the complex and brings it into close proximity to the substrate. Probably also stimulates CDC34 autoubiquitination. May be required for histone H3 and histone H4 ubiquitination in response to ultraviolet and for subsequent DNA repair. Promotes the neddylation of CUL1, CUL2, CUL4 and CUL4 via its interaction with UBE2M. Involved in the ubiquitination of KEAP1, ENC1 and KLHL41. In concert with ATF2 and CUL3, promotes degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. {ECO:0000269PubMed:10579999, ECO:0000269PubMed:11027288, ECO:0000269PubMed:15983046, ECO:0000269PubMed:16678110, ECO:0000269PubMed:16751180, ECO:0000269PubMed:18397884, ECO:0000269PubMed:19112177, ECO:0000269PubMed:19679664}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:11027288}. Nucleus {ECO:0000269PubMed:11027288}.
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Disease Associations |
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Tissue Specificity |
Widely expressed.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 213 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated |
Total |
213
[view]
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Protein-Protein |
213
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
13 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001841
Zinc finger, RING-type
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PFAM |
PF13639
PF14634
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PRINTS |
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PIRSF |
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SMART |
SM00184
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TIGRFAMs |
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Modification |
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SwissProt |
P62877
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PhosphoSite |
PhosphoSite-P62877
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
9978
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UniGene |
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RefSeq |
NP_055063
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HUGO |
HGNC:9928
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OMIM |
603814
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CCDS |
CCDS14009
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HPRD |
06794
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IMGT |
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EMBL |
AF140598
AF142059
AK315722
AL080242
AY099360
BC001466
BC017370
CH471095
CR456560
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GenPept |
AAD29715
AAD30146
AAH01466
AAH17370
AAM21718
BAG38078
CAB62925
CAG30446
EAW60403
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