InnateDB Protein
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IDBP-89816.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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NUP214
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Protein Name
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nucleoporin 214kDa
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Synonyms
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CAIN; CAN; D9S46E; N214; p250;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000352400
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InnateDB Gene
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IDBG-89810 (NUP214)
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Protein Structure
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Function |
May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex.
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Subcellular Localization |
Nucleus, nuclear pore complex. Note=Cytoplasmic filaments.
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Disease Associations |
Note=A chromosomal aberration involving NUP214 is found in a subset of acute myeloid leukemia (AML); also known as acute non-lymphocytic leukemia. Translocation t(6;9)(p23;q34) with DEK. It results in the formation of a DEK-CAN fusion gene.Note=A chromosomal aberration involving NUP214 is found in some cases of acute undifferentiated leukemia (AUL). Translocation t(6;9)(q21;q34.1) with SET.
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Tissue Specificity |
Expressed in thymus, spleen, bone marrow, kidney, brain and testis, but hardly in all other tissues or in whole embryos during development.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 57 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
57
[view]
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Protein-Protein |
57
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001680
WD40 repeat
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PFAM |
PF00400
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PRINTS |
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PIRSF |
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SMART |
SM00320
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TIGRFAMs |
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Modification |
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SwissProt |
P35658
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PhosphoSite |
PhosphoSite-P35658
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TrEMBL |
H0YDI2
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UniProt Splice Variant |
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Entrez Gene |
8021
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UniGene |
Hs.671104
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RefSeq |
NP_005076
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HUGO |
HGNC:8064
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OMIM |
114350
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CCDS |
CCDS6940
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HPRD |
00258
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IMGT |
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EMBL |
AB159230
AL157938
BC045620
BC105998
D14689
X64228
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GenPept |
AAH45620
AAI05999
BAA03515
BAD07398
CAA45535
CAI41111
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