InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NUP214

Summary

InnateDB Protein

IDBP-89816.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NUP214

Protein Name

nucleoporin 214kDa

Synonyms

CAIN; CAN; D9S46E; N214; p250;

Species

Homo sapiens

Ensembl Protein

ENSP00000352400

InnateDB Gene

IDBG-89810 (NUP214)

Protein Structure

UniProt Annotation

Function

May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex.

Subcellular Localization

Nucleus, nuclear pore complex. Note=Cytoplasmic filaments.

Disease Associations

Note=A chromosomal aberration involving NUP214 is found in a subset of acute myeloid leukemia (AML); also known as acute non-lymphocytic leukemia. Translocation t(6;9)(p23;q34) with DEK. It results in the formation of a DEK-CAN fusion gene.Note=A chromosomal aberration involving NUP214 is found in some cases of acute undifferentiated leukemia (AUL). Translocation t(6;9)(q21;q34.1) with SET.

Tissue Specificity

Expressed in thymus, spleen, bone marrow, kidney, brain and testis, but hardly in all other tissues or in whole embryos during development.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 57 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	57 [view]
Protein-Protein	57 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005487	nucleocytoplasmic transporter activity
GO:0005515	protein binding

Biological Process

GO:0000278	mitotic cell cycle
GO:0005975	carbohydrate metabolic process
GO:0006406	mRNA export from nucleus
GO:0006606	protein import into nucleus
GO:0006611	protein export from nucleus
GO:0007077	mitotic nuclear envelope disassembly
GO:0008645	hexose transport
GO:0010467	gene expression
GO:0010827	regulation of glucose transport
GO:0015758	glucose transport
GO:0016032	viral process
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0019221	cytokine-mediated signaling pathway
GO:0044281	small molecule metabolic process
GO:0045087	innate immune response (InnateDB)
GO:0051726	regulation of cell cycle
GO:0055085	transmembrane transport

Cellular Component

GO:0005634	nucleus
GO:0005643	nuclear pore
GO:0005654	nucleoplasm
GO:0005829	cytosol
GO:0005925	focal adhesion
GO:0043231	intracellular membrane-bounded organelle