InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TCF7L2

Summary

InnateDB Protein

IDBP-89867.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TCF7L2

Protein Name

transcription factor 7-like 2 (T-cell specific, HMG-box)

Synonyms

TCF-4; TCF4;

Species

Homo sapiens

Ensembl Protein

ENSP00000344823

InnateDB Gene

IDBG-89861 (TCF7L2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 58 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	58 [view]
Protein-Protein	44 [view]
Protein-DNA	7 [view]
Protein-RNA	1 [view]
DNA-DNA	6 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001103	RNA polymerase II repressing transcription factor binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0008134	transcription factor binding
GO:0019901	protein kinase binding
GO:0035257	nuclear hormone receptor binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0045295	gamma-catenin binding
GO:0070016	armadillo repeat domain binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001568	blood vessel development
GO:0006351	transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007050	cell cycle arrest
GO:0007420	brain development
GO:0008283	cell proliferation
GO:0009749	response to glucose
GO:0010909	positive regulation of heparan sulfate proteoglycan biosynthetic process
GO:0031016	pancreas development
GO:0032024	positive regulation of insulin secretion
GO:0032092	positive regulation of protein binding
GO:0032350	regulation of hormone metabolic process
GO:0042593	glucose homeostasis
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043570	maintenance of DNA repeat elements
GO:0044334	canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition
GO:0045444	fat cell differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046827	positive regulation of protein export from nucleus
GO:0048625	myoblast fate commitment
GO:0048660	regulation of smooth muscle cell proliferation
GO:0048699	generation of neurons
GO:0051897	positive regulation of protein kinase B signaling
GO:0060070	canonical Wnt signaling pathway
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:2000675	negative regulation of type B pancreatic cell apoptotic process
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0000790	nuclear chromatin
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005667	transcription factor complex
GO:0005737	cytoplasm
GO:0016605	PML body
GO:0032993	protein-DNA complex
GO:0070369	beta-catenin-TCF7L2 complex