Version 5.4
Homo sapiens Protein: TCF7L2
Summary
InnateDB Protein IDBP-89875.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TCF7L2
Protein Name transcription factor 7-like 2 (T-cell specific, HMG-box)
Synonyms TCF-4; TCF4;
Species Homo sapiens
Ensembl Protein ENSP00000358402
InnateDB Gene IDBG-89861 (TCF7L2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 58 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 58 [view]
Protein-Protein 44 [view]
Protein-DNA 7 [view]
Protein-RNA 1 [view]
DNA-DNA 6 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008013 beta-catenin binding
Biological Process
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0060070 canonical Wnt signaling pathway
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR013558 CTNNB1 binding, N-teminal
PFAM PF08347
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q5VVR7
UniProt Splice Variant
Entrez Gene 6934
UniGene Hs.706243
RefSeq
HUGO HGNC:11641
OMIM 602228
CCDS
HPRD 03751
IMGT
EMBL AL135792 AL158212 AL445486 AL451084
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca