InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TNFRSF1B

Summary

InnateDB Protein

IDBP-90093.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TNFRSF1B

Protein Name

tumor necrosis factor receptor superfamily, member 1B

Synonyms

CD120b; p75; p75TNFR; TBPII; TNF-R-II; TNF-R75; TNFBR; TNFR1B; TNFR2; TNFR80;

Species

Homo sapiens

Ensembl Protein

ENSP00000365435

InnateDB Gene

IDBG-90091 (TNFRSF1B)

Protein Structure

UniProt Annotation

Function

Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity. {ECO:0000269PubMed:12370298}.

Subcellular Localization

Isoform 1: Cell membrane; Single-pass type I membrane protein.Isoform 2: Secreted.Tumor necrosis factor-binding protein 2: Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 48 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	48 [view]
Protein-Protein	45 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005031	tumor necrosis factor-activated receptor activity
GO:0005515	protein binding
GO:0031625	ubiquitin protein ligase binding

Biological Process

GO:0006954	inflammatory response
GO:0006955	immune response
GO:0007166	cell surface receptor signaling pathway
GO:0007568	aging
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0032496	response to lipopolysaccharide
GO:0045087	innate immune response (InnateDB)
GO:0050728	negative regulation of inflammatory response
GO:0050779	RNA destabilization
GO:0051044	positive regulation of membrane protein ectodomain proteolysis
GO:0071222	cellular response to lipopolysaccharide
GO:0071363	cellular response to growth factor stimulus
GO:0097191	extrinsic apoptotic signaling pathway

Cellular Component

GO:0005576	extracellular region
GO:0005634	nucleus
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030424	axon
GO:0043025	neuronal cell body
GO:0043196	varicosity
GO:0045121	membrane raft
GO:0048471	perinuclear region of cytoplasm