Version 5.4
Homo sapiens Protein: DCLRE1A
Summary
InnateDB Protein IDBP-90194.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DCLRE1A
Protein Name DNA cross-link repair 1A
Synonyms PSO2; SNM1; SNM1A;
Species Homo sapiens
Ensembl Protein ENSP00000358311
InnateDB Gene IDBG-90190 (DCLRE1A)
Protein Structure
UniProt Annotation
Function May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons. {ECO:0000269PubMed:15542852}.
Subcellular Localization Nucleus {ECO:0000269PubMed:10848582, ECO:0000269PubMed:12446782, ECO:0000269PubMed:15572677}. Note=In some cells it may be found in typically 1 or 2 discrete nuclear aggregates of unknown function which also contain TP53BP1. Also found in multiple discrete nuclear foci which increase in number following treatment with ionizing radiation or interstrand cross- linking agents. These foci overlap with those formed by the MRN complex (composed of MRE11A, RAD50 and NBN) and BRCA1.
Disease Associations
Tissue Specificity Expressed in brain, heart, kidney, liver, pancreas, placenta and skeletal muscle. {ECO:0000269PubMed:12446782}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0016787 hydrolase activity
Biological Process
GO:0007067 mitotic nuclear division
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR001279 Beta-lactamase-like
IPR011084 DNA repair metallo-beta-lactamase
PFAM PF00753
PF07522
PRINTS
PIRSF
SMART SM00849
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6PJP8
PhosphoSite PhosphoSite-Q6PJP8
TrEMBL
UniProt Splice Variant
Entrez Gene 9937
UniGene Hs.712962
RefSeq NP_001258745
HUGO HGNC:17660
OMIM 609682
CCDS CCDS7584
HPRD 08519
IMGT
EMBL AL592546 AY607842 BC013124 BC062582 CH471066 D42045
GenPept AAH13124 AAH62582 AAT09762 BAA07646 CAI12637 EAW49489 EAW49490

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca