InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GTF3C5

Summary

InnateDB Protein

IDBP-90556.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GTF3C5

Protein Name

general transcription factor IIIC, polypeptide 5, 63kDa

Synonyms

TFiiiC2-63; TFIIIC63; TFIIICepsilon;

Species

Homo sapiens

Ensembl Protein

ENSP00000361180

InnateDB Gene

IDBG-90554 (GTF3C5)

Protein Structure

UniProt Annotation

Function

Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	43 [view]
Protein-Protein	39 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006383	transcription from RNA polymerase III promoter
GO:0010467	gene expression
GO:0035914	skeletal muscle cell differentiation
GO:0042791	5S class rRNA transcription from RNA polymerase III type 1 promoter
GO:0042797	tRNA transcription from RNA polymerase III promoter