InnateDB Protein
|
IDBP-90556.7
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
GTF3C5
|
Protein Name
|
general transcription factor IIIC, polypeptide 5, 63kDa
|
Synonyms
|
TFiiiC2-63; TFIIIC63; TFIIICepsilon;
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000361180
|
InnateDB Gene
|
IDBG-90554 (GTF3C5)
|
Protein Structure
|
|
Function |
Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters.
|
Subcellular Localization |
Nucleus.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
43
[view]
|
Protein-Protein |
39
[view]
|
Protein-DNA |
4
[view]
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
2 [view]
|
|
|
Molecular Function |
|
Biological Process |
GO:0006351
|
transcription, DNA-templated
|
GO:0006383
|
transcription from RNA polymerase III promoter
|
GO:0010467
|
gene expression
|
GO:0035914
|
skeletal muscle cell differentiation
|
GO:0042791
|
5S class rRNA transcription from RNA polymerase III type 1 promoter
|
GO:0042797
|
tRNA transcription from RNA polymerase III promoter
|
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR019136
Transcription factor IIIC, subunit 5
|
PFAM |
PF09734
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q9Y5Q8
|
PhosphoSite |
PhosphoSite-Q9Y5Q8
|
TrEMBL |
Q5T7U0
|
UniProt Splice Variant |
|
Entrez Gene |
9328
|
UniGene |
Hs.495417
|
RefSeq |
NP_001116295
|
HUGO |
HGNC:4668
|
OMIM |
604890
|
CCDS |
CCDS48050
|
HPRD |
16077
|
IMGT |
|
EMBL |
AF133124
AK055092
AK097295
AL162417
AY007123
BC009741
BC011355
BC017337
BC030157
CH471090
|
GenPept |
AAD41476
AAG01991
AAH09741
AAH11355
AAH17337
AAH30157
BAC04993
BAG51466
CAI13406
CAI13407
EAW88026
EAW88029
|
|
|