Version 5.4
Homo sapiens Protein: TRUB1
Summary
InnateDB Protein IDBP-90574.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRUB1
Protein Name TruB pseudouridine (psi) synthase homolog 1 (E. coli)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000298746
InnateDB Gene IDBG-90572 (TRUB1)
Protein Structure
UniProt Annotation
Function May be responsible for synthesis of pseudouridine from uracil in transfer RNAs. {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity Highly expressed in heart, skeletal muscle and liver. Expressed at lower levels in lung, small intestine, kidney and spleen. {ECO:0000269PubMed:12736709}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0009982 pseudouridine synthase activity
Biological Process
GO:0001522 pseudouridine synthesis
GO:0006396 RNA processing
GO:0008033 tRNA processing
GO:0009451 RNA modification
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR002501 Pseudouridine synthase II
IPR014780 tRNA pseudouridine synthase II, TruB
IPR020103 Pseudouridine synthase, catalytic domain
PFAM PF01509
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8WWH5
PhosphoSite PhosphoSite-Q8WWH5
TrEMBL B4DZ90
UniProt Splice Variant
Entrez Gene 142940
UniGene Hs.624483
RefSeq NP_631908
HUGO HGNC:16060
OMIM 610726
CCDS CCDS7591
HPRD 18229
IMGT
EMBL AF448144 AK125554 AK223567 AK302800 AK312805 AL355340 BC030601 BX648709
GenPept AAH30601 AAL40350 BAD97287 BAG35663 BAG54213 BAG64002 CAH10560 CAH73219

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca