InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PDPN

Summary

InnateDB Protein

IDBP-90588.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PDPN

Protein Name

podoplanin

Synonyms

AGGRUS; GP36; Gp38; GP40; HT1A-1; OTS8; PA2.26; T1A; T1A-2; T1A2; TI1A;

Species

Homo sapiens

Ensembl Protein

ENSP00000294489

InnateDB Gene

IDBG-90582 (PDPN)

Protein Structure

UniProt Annotation

Function

May be involved in cell migration and/or actin cytoskeleton organization. When expressed in keratinocytes, induces changes in cell morphology with transfected cells showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion. Required for normal lung cell proliferation and alveolus formation at birth. Induces platelet aggregation. Does not have any effect on folic acid or amino acid transport. Does not function as a water channel or as a regulator of aquaporin-type water channels. {ECO:0000250UniProtKB:Q62011, ECO:0000269PubMed:14522983, ECO:0000269PubMed:15231832, ECO:0000269PubMed:15515019, ECO:0000269PubMed:9651190}.

Subcellular Localization

Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell projection, filopodium membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell projection, lamellipodium membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell projection, microvillus membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell projection, ruffle membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Localized to actin-rich microvilli and plasma membrane projections such as filopodia, lamellipodia and ruffles. {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in placenta, lung, skeletal muscle and brain. Weakly expressed in brain, kidney and liver. In placenta, expressed on the apical plasma membrane of endothelium. In lung, expressed in alveolar epithelium. Up-regulated in colorectal tumors and expressed in 25% of early oral squamous cell carcinomas. {ECO:0000269PubMed:10393083, ECO:0000269PubMed:14522983, ECO:0000269PubMed:15515019}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0000902	cell morphogenesis
GO:0001946	lymphangiogenesis
GO:0006693	prostaglandin metabolic process
GO:0006928	cellular component movement
GO:0006954	inflammatory response
GO:0007155	cell adhesion
GO:0007165	signal transduction
GO:0007399	nervous system development
GO:0008283	cell proliferation
GO:0008360	regulation of cell shape
GO:0010572	positive regulation of platelet activation
GO:0016337	single organismal cell-cell adhesion
GO:0030324	lung development
GO:0030335	positive regulation of cell migration
GO:0035239	tube morphogenesis
GO:0048286	lung alveolus development
GO:0051272	positive regulation of cellular component movement
GO:0055093	response to hyperoxia
GO:2000045	regulation of G1/S transition of mitotic cell cycle

Cellular Component

GO:0001726	ruffle
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009897	external side of plasma membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0030027	lamellipodium
GO:0030175	filopodium
GO:0031258	lamellipodium membrane
GO:0031527	filopodium membrane
GO:0031528	microvillus membrane
GO:0032587	ruffle membrane