InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GSTA3

Summary

InnateDB Protein

IDBP-90833.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GSTA3

Protein Name

glutathione S-transferase alpha 3

Synonyms

GSTA3-3; GTA3;

Species

Homo sapiens

Ensembl Protein

ENSP00000211122

InnateDB Gene

IDBG-90829 (GSTA3)

Protein Structure

UniProt Annotation

Function

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Catalyzes isomerization reactions that contribute to the biosynthesis of steroid hormones. Efficiently catalyze obligatory double-bond isomerizations of delta(5)-androstene-3,17-dione and delta(5)- pregnene-3,20-dione, precursors to testosterone and progesterone, respectively. {ECO:0000269PubMed:15595823, ECO:0000269PubMed:20083122}.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004364	glutathione transferase activity
GO:0005515	protein binding

Biological Process

GO:0006749	glutathione metabolic process
GO:0006805	xenobiotic metabolic process
GO:0008152	metabolic process
GO:0044281	small molecule metabolic process
GO:1901687	glutathione derivative biosynthetic process

Cellular Component

GO:0005829

cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR003080 Glutathione S-transferase, alpha class
IPR004045 Glutathione S-transferase, N-terminal
IPR004046 Glutathione S-transferase, C-terminal
IPR010987 Glutathione S-transferase, C-terminal-like
IPR012336 Thioredoxin-like fold

PFAM