InnateDB Protein
|
IDBP-90858.5
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
RAB11FIP2
|
Protein Name
|
RAB11 family interacting protein 2 (class I)
|
Synonyms
|
nRip11; Rab11-FIP2;
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000347839
|
InnateDB Gene
|
IDBG-90852 (RAB11FIP2)
|
Protein Structure
|
|
Function |
A Rab11 effector binding preferentially phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and phosphatidic acid (PA) and acting in the regulation of the transport of vesicles from the endosomal recycling compartment (ERC) to the plasma membrane. Involved in insulin granule exocytosis. Also involved in receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from clathrin-coated vesicles. Required in a complex with MYO5B and RAB11 for the transport of NPC1L1 to the plasma membrane. Also acts as a regulator of cell polarity. {ECO:0000269PubMed:12364336, ECO:0000269PubMed:15304524, ECO:0000269PubMed:16251358, ECO:0000269PubMed:16775013, ECO:0000269PubMed:19542231}.
|
Subcellular Localization |
Cell membrane; Peripheral membrane protein. Recycling endosome membrane; Peripheral membrane protein. Note=Translocates with RAB11A from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
20
[view]
|
Protein-Protein |
20
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
1 [view]
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR000008
C2 domain
IPR019018
Rab-binding domain FIP-RBD
|
PFAM |
PF00168
PF09457
|
PRINTS |
PR00360
|
PIRSF |
|
SMART |
SM00239
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q7L804
|
PhosphoSite |
PhosphoSite-Q7L804
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
22841
|
UniGene |
Hs.713032
|
RefSeq |
NP_055719
|
HUGO |
HGNC:29152
|
OMIM |
608599
|
CCDS |
CCDS7602
|
HPRD |
10548
|
IMGT |
|
EMBL |
AB023158
AC022395
AY037299
BC075073
BC075074
CH471066
|
GenPept |
AAH75073
AAH75074
AAK68635
BAA76785
EAW49423
|
|
|