InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PLEKHM2

Summary

InnateDB Protein

IDBP-91073.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PLEKHM2

Protein Name

pleckstrin homology domain containing, family M (with RUN domain) member 2

Synonyms

SKIP;

Species

Homo sapiens

Ensembl Protein

ENSP00000364956

InnateDB Gene

IDBG-91071 (PLEKHM2)

Protein Structure

UniProt Annotation

Function

May play a role in the regulation of conventional kinesin activity. Required for maintenance of the Golgi apparatus organization. May play a role in membrane tubulation. {ECO:0000269PubMed:15905402}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:15905402}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019894	kinesin binding

Biological Process

GO:0007030

Golgi organization

Cellular Component

GO:0005737

cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR001849 Pleckstrin homology domain
IPR004012 RUN

PFAM

PF00169
PF02759

PRINTS

PIRSF

SMART

SM00233
SM00593

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8IWE5

PhosphoSite

PhosphoSite-Q8IWE5

TrEMBL

UniProt Splice Variant

Entrez Gene

23207

UniGene

Hs.646775

RefSeq

NP_055979

HUGO

HGNC:29131

OMIM

609613

CCDS

CCDS44063

HPRD

IMGT

EMBL

AB020649 AL121992 AL137297 AL450998 AL606758 BC008002 BC016488 BC030545 BC040441 BC042103 CH471167

GenPept

AAH08002 AAH16488 AAH30545 AAH40441 AAH42103 BAA74865 CAB70684 CAH70859 CAH72017 CAI22373 EAW51745