InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RGS10

Summary

InnateDB Protein

IDBP-91170.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RGS10

Protein Name

regulator of G-protein signaling 10

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000358097

InnateDB Gene

IDBG-91166 (RGS10)

Protein Structure

UniProt Annotation

Function

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Associates specifically with the activated forms of the G protein subunits G(i)-alpha and G(z)- alpha but fails to interact with the structurally and functionally distinct G(s)-alpha subunit. Activity on G(z)-alpha is inhibited by palmitoylation of the G-protein.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005096	GTPase activator activity

Biological Process

GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
GO:0038032	termination of G-protein coupled receptor signaling pathway
GO:0043547	positive regulation of GTPase activity