InnateDB Protein
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IDBP-91184.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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HMGCLL1
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Protein Name
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3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000309737
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InnateDB Gene
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IDBG-91174 (HMGCLL1)
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Protein Structure
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Function |
Non-mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy- 3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis, the products of which support energy production in nonhepatic animal tissues. {ECO:0000269PubMed:22847177, ECO:0000269PubMed:22865860}.
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Subcellular Localization |
Cytoplasm, cytosol. Endoplasmic reticulum membrane; Peripheral membrane protein.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000891
Pyruvate carboxyltransferase
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PFAM |
PF00682
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8TB92
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PhosphoSite |
PhosphoSite-Q8TB92
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
54511
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UniGene |
Hs.662317
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RefSeq |
NP_001274670
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HUGO |
HGNC:21359
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OMIM |
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CCDS |
CCDS75473
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HPRD |
13663
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IMGT |
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EMBL |
AK055075
AK127587
AK293856
AL590290
AL590406
BC024194
CH471081
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GenPept |
AAH24194
BAC87045
BAG51462
BAH11613
CAI40662
EAX04442
EAX04444
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