InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TIAL1

Summary

InnateDB Protein

IDBP-91187.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TIAL1

Protein Name

TIA1 cytotoxic granule-associated RNA binding protein-like 1

Synonyms

TCBP; TIAR;

Species

Homo sapiens

Ensembl Protein

ENSP00000358089

InnateDB Gene

IDBG-91185 (TIAL1)

Protein Structure

UniProt Annotation

Function

RNA-binding protein. Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasmic granule. Note=The cytoplasmic granules are stress granules which are a dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. Colocalizes with NANOS3 in the stress granules (By similarity). Cytoplasmic granules of cytolytic T-lymphocytes. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 62 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	62 [view]
Protein-Protein	47 [view]
Protein-DNA	0
Protein-RNA	15 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0017091	AU-rich element binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006915	apoptotic process
GO:0006952	defense response
GO:0007281	germ cell development
GO:0008284	positive regulation of cell proliferation
GO:0017145	stem cell division