Version 5.4
Homo sapiens Protein: NSMCE4A
Summary
InnateDB Protein IDBP-91647.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NSMCE4A
Protein Name non-SMC element 4 homolog A (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000358013
InnateDB Gene IDBG-91643 (NSMCE4A)
Protein Structure
UniProt Annotation
Function Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT- associated PML bodies (APBs). Is involved in positive regulation of response to DNA damage stimulus. {ECO:0000269PubMed:18086888}.
Subcellular Localization Nucleus {ECO:0000269PubMed:18086888}. Chromosome, telomere {ECO:0000305PubMed:18086888}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 21 [view]
Protein-Protein 21 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:2001022 positive regulation of response to DNA damage stimulus
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0005634 nucleus
GO:0030915 Smc5-Smc6 complex
Protein Structure and Domains
PDB ID
InterPro IPR014854 Non-structural maintenance of chromosome element 4, C-terminal
PFAM PF08743
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NXX6
PhosphoSite PhosphoSite-Q9NXX6
TrEMBL
UniProt Splice Variant
Entrez Gene 54780
UniGene Hs.258798
RefSeq XP_005269985
HUGO HGNC:25935
OMIM 612987
CCDS
HPRD 16585
IMGT
EMBL AF258584 AK000010 AK222487 AL731566 BC005212 BC062427
GenPept AAG23787 AAH05212 AAH62427 BAA90881 BAD96207 CAI14816 CAI14817

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca