InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SDHB

Summary

InnateDB Protein

IDBP-91735.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SDHB

Protein Name

succinate dehydrogenase complex, subunit B, iron sulfur (Ip)

Synonyms

CWS2; IP; PGL4; SDH; SDH1; SDH2; SDHIP;

Species

Homo sapiens

Ensembl Protein

ENSP00000364649

InnateDB Gene

IDBG-91733 (SDHB)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 47 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	47 [view]
Protein-Protein	47 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008177	succinate dehydrogenase (ubiquinone) activity
GO:0009055	electron carrier activity
GO:0016491	oxidoreductase activity
GO:0046872	metal ion binding
GO:0048039	ubiquinone binding
GO:0051536	iron-sulfur cluster binding
GO:0051537	2 iron, 2 sulfur cluster binding
GO:0051538	3 iron, 4 sulfur cluster binding
GO:0051539	4 iron, 4 sulfur cluster binding

Biological Process

GO:0006099	tricarboxylic acid cycle
GO:0006105	succinate metabolic process
GO:0009060	aerobic respiration
GO:0022904	respiratory electron transport chain
GO:0044237	cellular metabolic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005749	mitochondrial respiratory chain complex II
GO:0045273	respiratory chain complex II
GO:0070062	extracellular vesicular exosome