InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MPP1

Summary

InnateDB Protein

IDBP-92099.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MPP1

Protein Name

membrane protein, palmitoylated 1, 55kDa

Synonyms

AAG12; DXS552E; EMP55; MRG1; PEMP;

Species

Homo sapiens

Ensembl Protein

ENSP00000358547

InnateDB Gene

IDBG-92097 (MPP1)

Protein Structure

UniProt Annotation

Function

Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane; Lipid-anchor. Cell projection, stereocilium {ECO:0000250}. Note=Colocalizes with WHRN at stereocilium tip during hair cell development (By similarity). Colocalizes with MPP5 in the retina, at the outer limiting membrane (OLM). Colocalizes with WHRN in the retina, at the outer limiting membrane (OLM), outer plexifirm layer (OPL), basal bodies and at the connecting cilium (CC). Colocalizes with NF2 in non- myelin-forming Schwann cells. {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitous. {ECO:0000269PubMed:17584769}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.

Experimentally validated
Total	33 [view]
Protein-Protein	32 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004385	guanylate kinase activity
GO:0005515	protein binding

Biological Process

GO:0007165	signal transduction
GO:0046939	nucleotide phosphorylation
GO:0090022	regulation of neutrophil chemotaxis

Cellular Component

GO:0005622	intracellular
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0030863	cortical cytoskeleton
GO:0032420	stereocilium

Protein Structure and Domains

PDB ID

InterPro

IPR001452 SH3 domain
IPR001478 PDZ domain
IPR008144 Guanylate kinase-like
IPR008145 Guanylate kinase/L-type calcium channel beta subunit
IPR011511 Variant SH3 domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00018
PF14604
PF00595
PF13180
PF00625
PF07653

PRINTS

PR00452

PIRSF

SMART

SM00326
SM00228
SM00072

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt