InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: COL12A1

Summary

InnateDB Protein

IDBP-92647.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

COL12A1

Protein Name

collagen, type XII, alpha 1

Synonyms

BA209D8.1; COL12A1L; DJ234P15.1;

Species

Homo sapiens

Ensembl Protein

ENSP00000305147

InnateDB Gene

IDBG-92641 (COL12A1)

Protein Structure

UniProt Annotation

Function

Type XII collagen interacts with type I collagen- containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix. {ECO:0000250}.

Subcellular Localization

Secreted, extracellular space, extracellular matrix {ECO:0000250}.

Disease Associations

Tissue Specificity

Found in collagen I-containing tissues: both isoform 1 and isoform 2 appear in amnion, chorion, skeletal muscle, small intestine, and in cell culture of dermal fibroblasts, keratinocytes and endothelial cells. Only isoform 2 is found in lung, placenta, kidney and a squamous cell carcinoma cell line. Isoform 1 is also present in the corneal epithelial Bowman's membrane (BM) and the interfibrillar matrix of the corneal stroma, but it is not detected in the limbal BM. {ECO:0000269PubMed:9344363}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0030020	extracellular matrix structural constituent conferring tensile strength

Biological Process

GO:0001501	skeletal system development
GO:0007155	cell adhesion
GO:0022617	extracellular matrix disassembly
GO:0030198	extracellular matrix organization
GO:0030199	collagen fibril organization
GO:0030574	collagen catabolic process

Cellular Component

GO:0005576	extracellular region
GO:0005595	collagen type XII trimer
GO:0005615	extracellular space
GO:0005788	endoplasmic reticulum lumen
GO:0031012	extracellular matrix
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001791 Laminin G domain
IPR002035 von Willebrand factor, type A
IPR003961 Fibronectin, type III
IPR008160 Collagen triple helix repeat
IPR008985 Concanavalin A-like lectin/glucanases superfamily

PFAM

PF00054
PF02210
PF00092
PF00041
PF01108
PF01391

PRINTS

PIRSF

SMART

SM00210
SM00282
SM00327
SM00060

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q99715