Version 5.4
Homo sapiens Protein: OTUD3
Summary
InnateDB Protein IDBP-92780.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol OTUD3
Protein Name OTU domain containing 3
Synonyms DUBA4;
Species Homo sapiens
Ensembl Protein ENSP00000364261
InnateDB Gene IDBG-92778 (OTUD3)
Protein Structure
UniProt Annotation
Function Deubiquitinating enzyme that hydrolyzes 'Lys-6'- and 'Lys-11'-linked polyubiquitin. Also hydrolyzes heterotypic (mixed and branched) and homotypic chains. {ECO:0000269PubMed:23827681}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004843 ubiquitin-specific protease activity
Biological Process
GO:0006508 proteolysis
GO:0035871 protein K11-linked deubiquitination
GO:0044313 protein K6-linked deubiquitination
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR003323 Ovarian tumour, otubain
PFAM PF02338
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5T2D3
PhosphoSite PhosphoSite-Q5T2D3
TrEMBL Q0VDK5
UniProt Splice Variant
Entrez Gene 23252
UniGene Hs.374987
RefSeq NP_056022
HUGO HGNC:29038
OMIM 611758
CCDS CCDS41279
HPRD
IMGT
EMBL AB007928 AL391883 BC119636 BC134416
GenPept AAI19637 AAI34417 BAA32304 CAI17041

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca