InnateDB Protein
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IDBP-92796.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PLA2G2A
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Protein Name
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phospholipase A2, group IIA (platelets, synovial fluid)
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Synonyms
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MOM1; PLA2; PLA2B; PLA2L; PLA2S; PLAS1; sPLA2;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000364252
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InnateDB Gene
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IDBG-92794 (PLA2G2A)
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Protein Structure
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Function |
Thought to participate in the regulation of the phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides.
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Subcellular Localization |
Membrane; Peripheral membrane protein.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
27
[view]
|
Protein-Protein |
27
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0006644
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phospholipid metabolic process
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GO:0006654
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phosphatidic acid biosynthetic process
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GO:0010744
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positive regulation of macrophage derived foam cell differentiation
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GO:0016042
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lipid catabolic process
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GO:0034374
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low-density lipoprotein particle remodeling
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GO:0036148
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phosphatidylglycerol acyl-chain remodeling
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GO:0036149
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phosphatidylinositol acyl-chain remodeling
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GO:0036150
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phosphatidylserine acyl-chain remodeling
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GO:0036151
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phosphatidylcholine acyl-chain remodeling
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GO:0036152
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phosphatidylethanolamine acyl-chain remodeling
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GO:0044281
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small molecule metabolic process
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GO:0045087
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innate immune response (InnateDB)
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GO:0046473
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phosphatidic acid metabolic process
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GO:0046474
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glycerophospholipid biosynthetic process
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GO:0050729
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positive regulation of inflammatory response
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GO:0050830
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defense response to Gram-positive bacterium
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Cellular Component |
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PDB ID |
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InterPro |
IPR001211
Phospholipase A2
IPR016090
Phospholipase A2 domain
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PFAM |
PF05826
PF00068
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PRINTS |
PR00389
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PIRSF |
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SMART |
SM00085
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TIGRFAMs |
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Modification |
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SwissProt |
P14555
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PhosphoSite |
PhosphoSite-P14555
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TrEMBL |
A0A024RA96
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UniProt Splice Variant |
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Entrez Gene |
5320
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UniGene |
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RefSeq |
NP_001155200
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HUGO |
HGNC:9031
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OMIM |
172411
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CCDS |
CCDS201
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HPRD |
01397
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IMGT |
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EMBL |
AK291302
AL358253
AY462114
AY656695
BC005919
CH471134
CR456865
M22430
M22431
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GenPept |
AAA36549
AAA36550
AAH05919
AAR16084
AAT73043
BAF83991
CAG33146
CAH74017
EAW94907
EAW94908
EAW94909
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